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KMID : 0363220080460030424
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Korean Journal of Dermatology
2008 Volume.46 No. 3 p.424 ~ p.426
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A Case of Merkel Cell Carcinoma Differentially Diagnosed by Thyroid Transcription Factor-1
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Kim Mi-Hye
Kim Chan-Woo
Moon Seok-Ki
Shin Dong-Hoon
Choi Jong-Soo
Kim Ki-Hong
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Abstract
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Merkel cell carcinoma is a rare aggressive primary neuroendocrine skin tumor. It is more prevalent in elderly patients and commonly occurs as a solitary lesion on the head and neck. This case reports an 84-year old female with an asymptomatic 1×1.5 cm sized erythematous nodule on the right side of the nose that had rapidly enlarged over a one-month period. Histopathologically, it is difficult to differentiate Merkel cell carcinoma from metastatic small cell lung cancer. Thyroid transcription factor-1 (TTF-1) staining was very useful to differentiate Merkel cell carcinoma from metastatic small cell lung cancer. This case was positive for cytokeratin 20, but negative for TTF-1. We report a case that was diagnosed as Merkel cell carcinoma by TTF-1 staining. (Korean J Dermatol 2008; 46(3):424∼426)
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KEYWORD
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Merkel cell carcinoma, Thyroid transcription factor-1
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